Ua ʻike nā mea noiʻi e hoʻomau mau ka metabolite mua o THC ma muli o ka ʻikepili mai nā hiʻohiʻona ʻiole. Hōʻike ka ʻikepili noiʻi hou e hoʻomau mau ana ka metabolite THC koʻikoʻi i ka mimi a me ke koko e like me THC, inā ʻaʻole ʻoi aku. Hoʻonui kēia ʻike hou i nā nīnau ma mua o ka pane. Wahi a kahi noiʻi hou i paʻi ʻia ma ka Journal of Pharmacology and Experimental Therapeutics, ʻo ka metabolite psychoactive o THC, 11-hydroxy-THC (11-OH-THC), he like a ʻoi aku ka mana psychoactive ma mua o THC (Delta-9 THC).
ʻO ka haʻawina, i kapa ʻia ʻo "The Intoxication Equivalence of 11-Hydroxy-Delta-9-THC (11-OH-THC) Relative to Delta-9-THC," e hōʻike ana i ka mālama ʻana o nā metabolites THC i ka hana. Ua ʻike ʻia ʻo THC e wāwahi a hoʻoulu i nā mea hoʻonaninani hou i ka wā e decarboxylates a hana i loko o ke kino kanaka. "Ma kēia noiʻi ʻana, ua hoʻoholo mākou ʻo ka metabolite mua o THC, 11-OH-THC, e hōʻike ana i ka hana like a ʻoi aku paha ma mua o THC i loko o kahi ʻano hana cannabinoid kiʻi i ka wā e lawelawe pololei ʻia ai, ʻoiai e noʻonoʻo ana i nā ʻokoʻa o nā ala hoʻokele, ka wahine, pharmacokinetics, a me pharmacodynamics," wahi a ka noiʻi. "Ke hāʻawi nei kēia mau ʻikepili i nā ʻike koʻikoʻi i ka hana koʻikoʻi o THC metabolites, e hoʻomaopopo i ka noiʻi cannabinoid e hiki mai ana, a hoʻohālike i ka hopena o ka hoʻohana ʻana o THC a me ka metabolism i ka hoʻohana cannabis kanaka."
Ua alakaʻi ʻia kēia noiʻi e kahi hui mai Saskatchewan, Kanada, me Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, a me Robert B. Laprairie. I ka hoʻokolohua, ua hoʻopiʻi nā mea noiʻi i nā ʻiole kāne me 11-hydroxy-THC a nānā a aʻo i nā hopena o kēia metabolite THC i hoʻohālikelike ʻia me kona pūhui makua, Delta-9 THC.
Ua hōʻike hou nā mea noiʻi: "Ke hōʻike nei kēia mau ʻikepili i ka hoʻāʻo ʻana i ka huelo no ka ʻike ʻana i ka ʻeha, ʻo ka hana o 11-OH-THC he 153% ka THC, a ma ka hōʻike catalepsy, ʻo ka hana o 11-OH-THC he 78% ka THC.
No laila, hōʻike ka haʻawina e hiki ke hana koʻikoʻi ka THC metabolite 11-OH-THC i ka hana koʻikoʻi o ka cannabis. ʻO ka hoʻomaopopo ʻana i kāna hana ke lawelawe pololei ʻia e kōkua i ka wehewehe ʻana i nā haʻawina holoholona a me ke kanaka e hiki mai ana. Ua ʻōlelo ka hōʻike ʻo 11-OH-THC kekahi o nā metabolites mua ʻelua i hoʻokumu ʻia ma hope o ka hoʻohana ʻana i ka cannabis, ʻo ka mea ʻē aʻe ʻo 11-nor-9-carboxy-THC, ʻaʻole ia he psychoactive akā hiki ke noho i loko o ke koko a i ʻole ka mimi no ka manawa lōʻihi.
Wahi a ka US Centers for Disease Control and Prevention (CDC), i ka hoʻomaka ʻana o ka makahiki 1980, ʻo ka hoʻāʻo ʻana o ka mimi i kuhikuhi nui ʻia i ka 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), he metabolite o Delta-9-THC, ʻo ia ka mea nui o ka cannabis.
Hōʻike ka hōʻike ʻoiai ʻoi aku ka wikiwiki o ka puhi ʻana i ka cannabis ma mua o ka ʻai ʻana i nā meaʻai cannabis, ʻoi aku ka nui o ka 11-OH-THC i hana ʻia ma o ka ʻai ʻana ma mua o ka pua pua cannabis. Hōʻike ka hōʻike ʻo ia ke kumu e lilo ai nā meaʻai cannabis-infused e lilo i psychoactive a hoʻouluulu i ka poʻe mākaukau ʻole.
THC Metabolites a me ka ho'āʻo lāʻau
Hōʻike nā hōʻike e pili ana ka cannabis i nā mea hoʻohana ma muli o ke ala o ka hoʻokele. Ua hōʻike ʻia kahi noiʻi 2021 i paʻi ʻia ma ka Permanent Journal e ʻoi aku ka nui o nā hopena o ka ʻai ʻana i ka cannabis edibles ma mua o ka puhi ʻana i ka cannabis ma muli o ka metabolism o 11-OH-THC.
"ʻO ka bioavailability o THC ma o ka vaporization ʻo 10% a 35%," i kākau ai nā mea noiʻi. "Ma hope o ka absorption, komo ʻo THC i ke ake, kahi e hoʻopau ʻia ai ka hapa nui o ia mea i 11-OH-THC a i ʻole 11-COOH-THC, me ke koena THC a me kāna mau metabolites e komo i ke koko. ʻO ka hapalua o ke ola o THC i nā mea hoʻohana i kekahi manawa he 1 a 3 mau lā, ʻoiai i nā mea hoʻohana maʻamau, hiki ke lōʻihi i ka 5 a 13 mau lā.
Hōʻike nā haʻawina i ka lōʻihi ma hope o ka pau ʻana o nā hopena psychoactive o ka cannabis, hiki i nā metabolites THC e like me 11-OH-THC ke noho i loko o ke koko a me ka mimi no nā manawa lōʻihi. Hoʻopilikia kēia i nā ʻano hana maʻamau o ka hoʻāʻo ʻana inā pilikia nā mea hoʻokele a me nā mea pāʻani ma muli o ka hoʻohana ʻana i ka cannabis. No ka laʻana, ua hoʻāʻo nā mea noiʻi Australia e hoʻoholo i ka manawa i hiki ai i ka cannabis ke hōʻino i ka hana hoʻokele. I kekahi hihia, ua aʻo ʻo Thomas R. Arkell, Danielle McCartney, a me Iain S. McGregor mai ka Lambert Initiative ma ke Kulanui o Sydney i ka hopena o ka cannabis i ka hiki ke hoʻokele. Ua hoʻoholo ka hui e hōʻino ka cannabis i ka hiki ke hoʻokele no kekahi mau hola ma hope o ka puhi ʻana, akā pau kēia mau hemahema ma mua o ka hoʻomaʻemaʻe ʻia ʻana o nā metabolites THC mai ke koko, me nā metabolites e hoʻomau nei i ke kino no nā pule a i ʻole mau mahina.
"ʻO nā mea maʻi e hoʻohana ana i nā huahana THC pono e pale aku i ka hoʻokele a me nā hana ʻē aʻe e pili ana i ka palekana (e laʻa, ka hana ʻana i nā mīkini), ʻoi aku hoʻi i ka wā mālama mua a no kekahi mau hola ma hope o kēlā me kēia maʻi," i kākau ai nā mea kākau. "ʻOiai inā ʻaʻole manaʻo ka poʻe maʻi i ka hemahema, hiki iā lākou ke hoʻāʻo i ka maikaʻi no THC. Eia kekahi, ʻaʻole hoʻokuʻu ʻia nā poʻe maʻi cannabis lapaʻau i kēia manawa mai ka hoʻāʻo ʻana i ka lāʻau lapaʻau ma ke alanui a me nā hoʻopaʻi kānāwai e pili ana."
ʻO kēia noiʻi hou ma 11-OH-THC e hōʻike ana he nui nā noiʻi e pono ai e hoʻomaopopo hohonu i ka hopena o nā metabolites THC i ke kino o ke kanaka. Ma o nā hana hoʻomau wale nō e hiki ai iā mākou ke wehe piha i nā mea huna o kēia mau pūhui kūʻokoʻa.
Ka manawa hoʻouna: Mar-21-2025